Actos
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I posted several months ago to see if anyone had their child on Actos? I was just wondering about the progress for I have seen it in my dd. Hi Jenni, We are currently using Actos (started in November) I don't really know if there has been a difference or not because we started some Supplements around the same time. I just noticed that your post was from 2006 -  I posted the same thing a few months ago, but did not get any replies! Did you get the prescription from a DAN Dr.?? We did. I'm curious if this may be the same dr., or the same city as no one else seems to know about it.We only did it for about 2 weeks, because we got afraid seeing as no one else was doing it. Also therapist had told us the dosages were all guess work, so she thought it wasn't a good idea. It did actually seem to make a bit of a difference cognitvely, but that may have just been a fluke? I hope people respond to this thread. I plan on bumping it if not - sorry guys. I had to do a double take when I saw this post because I did post it a while ago. I did get a script for Actos for both my children. My kids were very responsive to it. I saw immediate results with my son w/in 24 hours and saw improvements with my daughter after about a good 6 weeks. Both kids kept making improvements while they were on it. When I switched DAN docs, we switched to spironolactone, which I wasn't expecting to see improvements because I assumed Actos did the trick. Both kids were responders to spironolactone w/in 24 hours. Spiro has a long record of use (saefly) with children. Actos does not. I know some kids who do not respond to either treatments as dramatically as my kids. This is something you want to ask the DAN about - at what point do you decide to stop. Here is the paper for Actos: http://www.jneuroinflammation.com/content/1/1/3 Here is the paper for spironolactone: http://www.vitalitywellness.com/education/pdfs/Spironolacton e.pdf Thanks for the advice Jenni, I want to look into the Spironolacton. We haven't noticed anything with the Actos and it has been since November. For what it's worth, I just found this study - it wasopen label, but they had pretty impressive results in the 25 kids they tried Actos on. If the dosing was guesswork, at least it was guessing in the "safe" range where there were no adverse reactions. http://www.pubmedcentral.nih.gov/articlerender.fcgi? artid=1781426 Actos. For Autism??? I take it myself for Diabetes, but have NEVER heard of this. Thanks for the article links ... I want off it b/c it is supposed to add "lower depot" fat ... reposting second link ... http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=178142 6&blobtype=pdf Jsut read both ... WOW maybe I better stay on it! Well, one day not too long ago we were at wits' end (as usual), and I was thinking on the often posed question: "what can we do..." with the implied RIGHT NOW! in the picture. I've read umpteen piles of drivel lately that boil down to "inflammation --> autism" and what does every American have stocked in their medicine cabinet? NSAIDs (Non Steroidal Anti-Inflammatory Drugs, such as Motrin, Tylenol, Aspirin, etc.) So, our little guy is pretty responsive to Motrin in terms of breaking fevers, and it has been apparently harmless in the past, so why not? Well, for starters, he is very suspicious of any doctored food or drink, and absolutely refuses to take a spoon or dropper of medicine, but he still did drink a children's dose of Motrin in a glass of milk, and it did seem to offer slight symptomatic relief, sort of blunted the deep dark valley of the low spot he was going through. Placebo effect? Certainly a possibility. But it got me wondering about the use of anti-inflammatory drugs and led to the paper on Actos. My son, like Jennifer's children, responded miraculously to spironolactone immediately. |
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