Methyl B-12 Rx Concerns Oh I see someone else is interested in this subject too...Please see the thread I kicked up for my own concerns.  My doctor who is not an alternative or DAN doctor prescribed the methyl b-12 injectable kind for my little boy who is now 4yrs old and diagnosed with autism. Here is the Rx information: methycobalamin (25mg/ml) 12.9 mg or 0.5ml injected every 3 days. insuline syringes #30 or 3d *cant tell the handwriting LOL* according to Dr Nuebrander's website he recommends "64.5 mcg/kg once every 3 days to the adipose tissue of the buttocks at an angle severe and horizontal enough to guarantee a “shallow” subcutaneous delivery from a BD 3/10 cc insulin syringe with an 8 mm, 31-gauge needle, item #328438 only, and made from a 25 mg/ml methyl-B12 stock solution" http://www.drneubrander.com/Files/Methyl-B12;%20Myth,%20Mast erpiece,%20or%20Miracle.doc I am concerned that his pediatrician prescribed maybe an inadequate prescription. I see some differences. Not sure. For those who tried it and still using it for your children, did your doctor follow Nuebrander's method? If not did you still see results? Do you even see results concerning Nuebranders method? Did anybodys doctor prescribe it like mines? Does that kind work? Highly concerned!!! I rather get it right the first time so I can properly see if this works for my little boy.... How much does your son weigh?  Dosage is based upon weight....I believe he is 45 poundsYou are 10 times the dose Dr. Neubrander recommends for a 45 pound child. Rick Neubrander My son gets 4 units and he is 2 1/2 and weighs 28 lbs.  He also uses the 25mg/ml concentration and he sees Dr. Neubrander.  So I think .05 ml's is pretty high.  Are you sure he is not getting 5 units.  Because if he is using a insulin needle then that only goes to 30 units and so he would be getting I think the right dosage.  Unless they gave you a 1 ml syringe and then .5 ml's would still be too high.  Sorry if I coonfused you more but check to make sure your syringe says .5 ml's or 5 units. Oh, I see Rick responded.  So I guess there is your answer.  He is Dr. Neubranders brother who works in his office. OK I'm going to just put my concern here as no one answered on the other thread I'd kicked up earlier.  I realize there has been one study saying it tended to help [at least some] autistic kids but IF you suspect mercury you might want to proceed with caution. ..if our kids do have mercury issues I'm afraid it could wind up making methyl mercury [or an even more toxic kind] in the body....This possibility was brought up by my chem major son.  I recently wrote a vitamin company [who specializes in making vitamins for autistic kids] expressing these concerns, asking they perhaps change their product from oral methylcobalamin to the type used in England... I haven't heard back from them...Sorry to be a wet blanket but wanted to raise this concern; I wish an MD would consider and comment on this.  While I was doing research to help answer this question I came across MB12 lollipops? Are these for real? Anyone know anything about them? The point that caseyp57 makes is concerning to me also. Can anyone expand on that? All I can say is that my son has been on MB12 injections or spray for almost 3 years now and we have had no rises in his body burden of mercury.  Also, yes the MB12 lollipops are for real and get good reviews from parents. All I can say is that my son has been on MB12 injections or spray for almost 3 years now and we have had no rises in his body burden of mercury. ............. Well no the idea isn't that it might increase a mercury problem [there's no mercury in methylcobalamin],  just that it might change the mercury in the body already into a more dangerous type of mercury. From Wikipedia for example on methylcobalamin: It is produced preferentially by some species of bacteria. If these come into contact with heavy metals in the environment, these may become methylated forms of the metal which, in the case of methylmercury, is highly toxic.[2] When you look up the link: Comprehensive B12: Chemistry, Biochemistry, Nutrition, Ecology, Medicine  By Zenon Schneider, Andrzej Stroiński http://books.google.co.uk/books?id=OBlxCKbYCx8C&pg=PA32# v=onepage&q&f=false It reads: "The methylated metals are invariably more toxic than their inorganic substrates....Other metal ions that are known to react with methylcobalamin ...are lead, thallium and palladium. ...." If you ask the doctor who Rxed this about it please let us know what he/she says. Also wanted to add that I looked again at the abstract on the two studies on methylb12 and autism: http://www.ncbi.nlm.nih.gov/pubmed/19056591 http://www.ncbi.nlm.nih.gov/pubmed/15585776 And noticed they both also used folinic acid, so I'm just wondering if that was partly responsible for the success of these trials; also we don't know whether these kids had any pre-existing problem with mercury or not. [Maybe the researchers did but the info. is not in the abstracts.] But again, I'm no expert, and I'd like to hear from a doctor [or doctors] on the subject. I feel it's foolish not to raise these types of questions though when beginning something new. After hearing back from JulieA (Thank you by the way!) I decided to check out the lollipops but they were expensive. I sent them an email asking if there was any cheaper way to obtain them and linked them to this topic and they gave me a code for 10% off to share. I'm assuming since they named the code after the forum it should work for you guys also. http://www.revitapop.com/shop_promo.php code: autismpdd10http://www.ncbi.nlm.nih.gov/sites/entrez Just wanted to say I found this article: The effect of methylcobalamin on the toxicity of methylmercury and mercuric chloride on nervous tissue in culture. Kasuya M. Abstract Methylcobalamin (methyl-B12, vitamin B12 analog) at a concentration of 0.2 x 10(-5) M tended to inhibit the toxic effect of 1 and 1.5 x 10(-5) M methylmercuric chloride (MMC) on the development of nerve fibers, glial cells and fibroblasts from newborn rat cerebellum explants. Methyl-B12 at greater than 1 x 10(-5) M significantly inhibited the toxic effect of 1 and 1.5 x 10(-5) M MMC. However, the protective effect of methyl-B12 against the toxicity of mercuric chloride (MC) was not significant. These results are in accord with an interaction of alkyl mercurials with membranes of nervous tissue, producing the degenerative changes in the cells, since vitamin B12 increases the lipid synthesis in nervous tissue. The results also indicate that the mechanism of toxic action of organic mercury is different from that of inorganic mercury. So maybe we will still try the methylb12 we had bought for our son after all.... Would still like to talk with an MD about it though or wish someone with some background in medicine/research would comment-- my son admits he doesn't know much about how this all might work in living organisms but I thought it was a legitimate concern/question -- and I also wish there was another similar study as above was done since 1980...God bless.
	Copyright Autism-PDD.net