Question - Renal problems/Autism? | Autism PDD
Hi, just wanted to ask anyone out there if they know of any connection between renal problems and Autism?? 
Does anyone know of someone affected by Autism along with either of the following conditions~
Ureteric reflux, kidney cysts or any renal problem for that matter?
any response would be appreciated. 
I don't personally know of anyone with autism who also has renal disease. However, I have read of several genetic syndromes where autism and renal conditions sometimes coexist. However, from what I read most of these syndromes have other symptoms or deformities that go along with the syndrome, but they might be worth looking at.
Purine Autism http://www.purineresearchsociety.org/
Tuberous Sclerosis http://www.tsalliance.org/
Mitochondrial Disease http://www.kathleensworld.com/mitochon.html
My DS (Asperger's, ADD, Anxiety Disorder) in all likelyhood has polycystickidney disease, inherited from my DH, who had a transplant in 1996. I
suspect DH is on the spectrum as well, though he has only been dx'd as
OCD. I've never heard any mention that there may be a connection
between the AS and PKD.
Karen,
I found the following when I was researching Tuberous Sclerosis that you may be interested in. http://www.ninds.nih.gov/disorders/tuberous_sclerosis/detail _tuberous_sclerosis.htm
"Some individuals with TSC may also have a developmental disorder called autism."
"Kidney problems such as cysts and angiomyolipomas occur in an estimated 40 to 80 percent of individuals with TSC, usually occurring between ages 20 and 30. Cysts are usually small, appear in limited numbers, and cause no serious problems. Approximately 2 percent of individuals with TSC develop large numbers of cysts in a pattern similar to polycystic kidney disease2 during childhood. In these cases, kidney function is compromised and kidney failure occurs. In rare instances, the cysts may bleed, leading to blood loss and anemia."
[QUOTE=gabu]
Karen,
I found the following when I was researching Tuberous Sclerosis that
you may be interested in. tuberous_sclerosis/detail_tuberous_sclerosis.htm"> http://
www.ninds.nih.gov/disorders/tuberous_sclerosis/detail
_tuberous_sclerosis.htm
"Some individuals with TSC may also have a developmental disorder
called autism." </TOPIC_>
"Kidney problems such as cysts and
angiomyolipomas occur in an estimated 40 to 80 percent of
individuals with TSC, usually occurring between ages 20 and 30.
Cysts are usually small, appear in limited numbers, and cause
no serious problems. Approximately 2 percent of individuals with TSC
develop large numbers of cysts in a pattern similar to polycystic kidney
disease<SUP>tuberous_sclerosis/
detail_tuberous_sclerosis.htm#two">[COLOR=#800080">2[/COLOR" ></
SUP> during childhood. In these cases, kidney function is compromised
and kidney failure occurs. In rare instances, the cysts may bleed,
leading to blood loss and anemia."
[/QUOTE]
Thanks for the info, but there is no question that it is PKD that runs in
DH's family. His father died from it in 1961. His sister has it and had a
transplant about 15 years ago (BIL donated kidney - he's the only one of
the three sibs that doesn't have it). DH recieved a cadaver kidney in '96
and is doing great. Lucky for him he never had to go on dialysis. DS had
an ultrasound when he was 18 months that showed two small cysts on his
left kidney. Not enough to make a definitive dx, but given the family
history...PKD Foundation recommends not getting a dx during
adolesence, since there is absolutely no onset or treatment at this age,
and would only give an insurance company reason to drop him, so we will
probably stay away from a dx for at least another 10 years. Same goes
for DD. We have a 50% chance of passing on the disease with each
pregnancy, but my gut tells me DD doesn't have it. Not very scientific,
just a mother's intuition.
Thanks for everyones reply's.. I hadn't heard of Tuberous Sclerosis before but have just clicked on the link to check out the symptoms etc..
A Q: for Karen, was your daughter diagnosed with Tuberous Sclerosis at birth? If not when did the cyst first become evident on the kidneys?
If I'm understanding correctly, no one in Karen's family has TS, we do in our family. My hubby and daughter do.
THey found Jessi's TS for sure at 5 months of age as a result of her seizures and MRI. She's had two brain surgeries due to the epilepsy and is doing really well seizure wise right now.
They found her kidney cysts at 18 months, I think. Her previous ultrasounds had come back clear.
Sarah
So sorry Sarahtotally misread the above posts..
thanks for sharing your info. So you are saying that the cysts were not evident till 18mths, does she have regular scans now to monitor the growth?
Chantelle
She'll get checked yearly, unless we see any problems. If they don't grow, then they will only need to be checked every 3 years.
Yep, they didnt' see them until 18 months, and my husband didn't have them at all until his early 20's.
Sarah
editedmonths and had two small cysts on his left kidney. He is almost 11 years
old and has not had an ultrasound since then. DD has not had an
ultrasound since her birth. She is 3 1/2. I had never heard of TS until
this thread. Like I said before, PKD is all we have been dealing with, but
forturnately it is the adult type and not the juvenile type. DH's family
history is renal failure in the mid to late 30's. DH was 36 when he had his
transplant.
Hi-
My daughter, 28 months, has Autism, but has the genetic disease Tuberous Sclerosis. Jessi has multiple cysts on her kidneys. It comes from her disease, though, not autism.
Sarah
Karen-
People with Tuberous Sclerosis can have PKD. That's what my daughter most likely has, and we know for sure my husband has. THe genetic mutation of their TSC2 gene is right next to the PKD1 gene. So there's a link there for people with TS to develop PKD if they have TSC2 and not TSC1. But, that's relatively new research.
Just putting in that TS people have PKD also.
Sarah
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